B.S. Exercise Physiology, West Virginia University (2007-2012)
Ph.D. Nutritional Sciences, University of Kentucky (2012-Present)
Cancer, Energy Metabolism, Metabolomics, Oxidative Stress, MnSOD
Cancer biologists have recognized altered metabolism in cancer cells since the late 1920s, and altered metabolism was recognized as a hallmark of cancer in 2011. However, despite over 80 years of research, the mechanisms leading to altered metabolism and its role in cancer development is unknown. The St. Clair lab found that these metabolic changes are preceded by a sudden drop in manganese superoxide dismutase (MnSOD) activity in the earliest stages of cancer development. Given mitochondria’s role in regulating metabolism and MnSOD’s importance in defense against mitochondrially-derived oxidative stress, it is reasonable to connect the drop in MnSOD activity with the advent of altered metabolism seen in cancer. My work focuses on drawing this connection and determining a mechanism through which MnSOD deficiency may drive the aberrant cellular metabolism observed in cancer cells.
2014 Zhao Y, Miriyala S, Miao L, Mitov M, Schnell D, Dhar S, Sultana R, Butterfield DA and St. Clair DK. Proteomic identification of HNE-bound mitochondrial proteins in Cardiomyocytes after Doxorubicin treatment in mice. Free Radic Biol Med. 2014 Mar 12. pii: S0891-5849(14)00107-5. doi: 10.1016/j.freeradbiomed.2014.03.001.
2013 Schnell DM, St. Clair DK. Redox Pioneer: Joe M. McCord. Antioxidant and Redox Signaling. 2014 Jan 1;20(1):183-8. Epub 2013 Nov 12.
2013 Baseler WA, Dabkowski ER, Jagannathan R, Thapa D, Nichols CE, Shepherd DL, Croston TL, Powell M, Razunguzwa TT, Lewis SE, Schnell DM, Hollander JM. Reversal of Mitochondrial Proteomic Loss in Type 1 Diabetic Heart with Overexpression of Phospholipid