University of Oxford (2017-2021, anticipated)
University College London (2014-2015)
MSc Infection and Immunity
Western Kentucky University (2010-2014)
BA Biology; BA Chemistry
My dissertation project underscores the intersection between cellular metabolism, cell-intrinsic immunity, and viral entry. Specifically, I am investigating how HIV entry modulates well-established biomarkers of metabolism and whether discrete host cellular bioenergetic states alter the success of HIV entry and fusion via FRET-FLIM based approaches. Simultaneously, I am broadly investigating the role of master metabolic regulator mTOR and its influence on viral fusion by determining if its activity is linked to well-known players in viral restriction that act during viral entry. This work will ultimately add to the existing knowledge of several intracellular processes that can be potentially targeted for alternative therapeutic strategies to control HIV replication in infected patients.
C. Coomer, M. Iliopoulou, R. Nolan, M. Jakobsdottir, L. Alvarez, S. Padilla-Parra. Quantifying Single-Cell Global Metabolic Consequences and Influences of HIV-1 Entry via Live-Cell Imaging Approaches. In preparation for Journal of Biological Chemistry.
C. Coomer and S. Padilla-Parra (2018). Towards quantitative imaging of HIV-1 transmission in tissue. Submitted to Frontiers in Immunology.
M. Iliopoulou, R. Nolan, L. Alvarez, Y. Watanabe, C. Coomer, et al (2018). A dynamic three step mechanism drives the HIV-1 prefusion reaction. Nature Structural and Molecular Biology. https://doi.org/10.1038/s41594-018-0113-x.
Kearney, M.F., Anderson, E.M., Coomer, C., Smith, L., Shao, W., Johnson, N., Kline, C., Spindler, J., Mellors, J.W., Coffin, J.M., and Ambrose, Z. (2015) Well-mixed plasma and tissue viral populations in RT-SHIV-infected macaques implies a lack of viral replication in the tissues during antiretroviral therapy. Retrovirology 12: 93.
Pope, W.H., et al (2015). Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity. eLife; 4: e06416
M.F. Kearney; L. Smith; C. Coomer; G.J. Besson; J. Spindler; E.M. Anderson; W. Shao; T. Tanzosh; C. Rehm; J.W. Mellors; J.M. Coffin; F. Maldarelli. No Evidence for Evolution of Plasma HIV-1 RNA or PBMC HIV-1 DNA During Long-Term Suppressive Antiretroviral Therapy. In preparation for PLoS Pathogens.
Hatfull, G.F., et al (2012). Complete Genome Sequences of 138 Mycobacteriophages. Journal of Virology. 86: 2382-2384